Liver microRNA Profile of Induced Allograft Tolerance

Early tolerance in pediatric liver allograft recipients.

The authors report on six pediatric liver transplant recipients for whom allograft tolerance occurred shortly after transplantation (ie, less than 1.5 years). All the patients had associated life-threatening viral complications. They are currently immunocompetent. The tolerant state may be related to the development of a TH2 cytokine pattern.

Murine liver allograft transplantation: tolerance and donor cell chimerism.

Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse-strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity had 20% and 33% survival of more than 100 days, but the other 11 combinations, including four that were fully allogeneic and all with only class ...

microrna and renal allograft monitoring

MicroRNA and Renal Allograft Monitoring

Implication for health policy/practice/research/medical education: Renal allograft monitoring is a great challenge of transplantation medicine and different biomarkers have been proposed. MicroRNA is an appealing biomarker because we could trace it from different sources including biopsy samples urine and blood, particularly, miRNA signature of stable and impending to failure allograft in urin...

Split Tolerance Induced by Orthotopic Liver Transplantation

Spontaneous orthotopic liver allograft acceptance associated with microchimerism in mice induces tolerance to subsequent skin or heart transplants from the donor but not third-party animals. Despite in vivo hyporesponsiveneu, in vitro MLC and CTL assays showed continuing anti donor reactivity. Cells isolated from recipients' spleens and grafted livers, when tested in MLC and CTL assays, were an...